A bunch of young people are invited to a Caribbean cruise on a gangster's yacht, to distract the attention of the authorities. Unfortunately, a mutant cat which escaped from a test laboratory also gets on board, and kills most of the passengers.
Lonnie, a crop duster pilot, must lead a mismatched group of survivors to escape the deadly zombie horde after an experimental chemical, intended to control the invasive kudzu vine, transforms the citizens of Charleston, MS into zombies.